Starting a new school year, Squish, a meek amoeba who loves the comic book exploits of his favorite hero, Super Amoeba, is determined to get picked for kickball and hang out with the cool kids.
The young amoeba Squish, inspired by his favorite comic book hero, Super Amoeba, tries to navigate his way through school and save his friends and the world from the evils that lurk in the halls.
When Babymouse decides to become president of the student council, she learns that there is more to running for office than being famous and in charge.